In my experience, monsters are pretty tolerable with a sorc that has 105% FCR and 86% FHR breakpoints. You can just keep hopping around with teleport without getting snagged on monsters, and I typically have Glacial Spike on left click to freeze a pack if I can't avoid them. I avoid doing that as much as possible... any monster interaction seems to waste time and worsen my runs.
Coju's points are very interesting. I recently did two sets of 5k LK runs on two different maps. The first map gave me zero Los and Ohms, while the second map gave me 2 Los and 6 Ohms. Another interesting thing was the first map gave me 14 Pul and the second only gave 7.
That did make me wonder if certain maps have a predisposition for certain drop patterns, or if the maps forcing me to approach the chests a certain way forced certain drops patterns, but I suppose two sets of 5k runs is a pretty small sample size and with a random number generator, really anything is possible. The weird mrllamasc thing with the Mal seems some confirmation, but I'd hazard it would be hard to experiment enough to get it consistent with an actual map.