I've always said that LK runs are more interesting and less boring if you pop all the stuff along the way to the "superchests".
i'm not even all that convinced that the superchests pay better than all the rando poppables along the way. Especially if you have a quicker character. Popping potentially 6 chests in 2 campfires and then loading takes a certain amount of time ... popping all the stuff along the way, in my mind, certainly increases your odds for a decent rune. I'm pretty certain that i've found more high runes from poppables than the chests.
I've been levelling a WW barb since the 2.4.3 changes and with my Enigma and the run speed he's pretty quick at popping stuff.
*edit* trying to attach a pic but it says server can't do it, pic size too large. Strange, worked before*
anyways, found a Ber rune from a rando single small chest.